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Tumor-associated humoral cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy

✍ Scribed by R. Fäldt; J. Ankerst

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
709 KB
Volume
20
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Sera of eight unselected adult patients with acute myelogenous leukemia obtained before and after chemotherapy were repeatedly tested for specific complement‐dependent cytotoxicity against autochthonous peripheral white blood cells from the acute leukemia stage and from the remission stage, respectively. Complement‐dependent cytotoxicity against white blood cells from the acute leukemia stage was demonstrated in all of the eight patients, while none of three patients' sera were reactive against white blood cells from the remission stage tested in parallel. The cytotoxicity was increased after chemotherapy, also in those patients in whom remission was not achieved.

📜 SIMILAR VOLUMES

Demonstration of antibody-associated cel
Demonstration of antibody-associated cellular cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy
✍ R. Fäldt; J. Ankerst 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 814 KB

## Abstract This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from