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Tumor angiogenesis of non–small cell lung cancer

✍ Scribed by Noriharu Shijubo; Hiroshi Kojima; Manabu Nagata; Takashi Ohchi; Akihiro Suzuki; Shosaku Abe; Noriyuki Sato

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
130 KB
Volume
60
Category
Article
ISSN
1059-910X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Lung cancer is one of the commonest causes of cancer death in developed countries. Recent evidence suggests that angoigenesis is related to poor prognosis in many solid tumors including non–small cell lung cancer (NSCLC). Angiogenesis is regulated by a complex interaction among growth factors and cytokines and influenced by proteolytic enzymes such as plasminogen activators and matrix metalloproteases, expression of adhesion molecules, and distribution of extracellular matrices. Fibroblasts, macrophages, mast cells, and endothelial cells themselves also affect angiogenesis. This review concentrates on angiogenic growth factors including vascular endothelial growth factor, angiopoietins, platelet derived endothelial growth factor, and basic fibroblast growth factor, proteases, adhesion molecules including vascular endothelial cadherin and integrins, osteopontin, and mast cell products in tumor angiogenesis of NSCLC. Microsc. Res. Tech. 60:186–198, 2003. © 2003 Wiley‐Liss, Inc.

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