𝔖 Bobbio Scriptorium
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Tuftsin induced tumor necrosis activity

✍ Scribed by Marek S. Wleklik; Miroslaw Luczak; Victor A. Najjar

Book ID
104673848
Publisher
Springer
Year
1987
Tongue
English
Weight
482 KB
Volume
75
Category
Article
ISSN
0300-8177

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✦ Synopsis

Tuftsin induced tumor necrosis activity was investigated. The activity was found in mice serum several days after i.p. injection of tuftsin. Further experiments with adhering peritoneal and spleen cells indicated that macrophages were the source of the observed activity. The same effect was observed when promyelocytic leukemia cells (HL60) were stimulated with different concentrations of the peptide. These showed yet another possible mechanism for tuftsin antineoplastic activity.

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## Abstract TNF is a cytokine with potent antitumor activity in murine models and when administered clinically __via__ regional perfusion. There is substantial evidence that this antitumor activity depends in large part on TNF's procoagulant effect on tumor neovasculature, which is mediated by indu