Tucupentol, a Novel Mono-tetrahydrofuranic Acetogenin from Annona montana, as a Potent Inhibitor of Mitochondrial Complex I

✍ Scribed by Olga Álvarez Colom; Adriana Neske; Nadia Chahboune; M. Carmen Zafra-Polo; Alicia Bardón

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 170 KB
• Volume: 6
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200800102

✦ Synopsis

Abstract

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Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono‐tetrahydrofuran‐pentahydroxy‐acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin‐A, cis‐annonacin‐10‐one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8–5.4‐nM range.