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Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

✍ Scribed by Astrinidis, Aristotelis; Cash, Timothy P; Hunter, Deborah S; Walker, Cheryl L; Chernoff, Jonathan; Henske, Elizabeth P


Book ID
110067099
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
198 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract We investigated the effects of overexpression of the tuberous sclerosis‐1 and ‐2 (__TSC1/2__) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previously in fibroblasts, 293 cells over