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Tu1936 Case-Control Study and Meta-Analysis of Glutathione S-Transferase Polymorphisms in Patients With Inflammatory Bowel Disease

✍ Scribed by Broekman, Mark M.; Morsche, Rene te; Roelofs, Hennie M.; Hoentjen, Frank; Peters, Wilbert H.; Wanten, Geert; De Jong, Dirk J.


Book ID
122126641
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
54 KB
Volume
146
Category
Article
ISSN
0016-5085

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## Background: Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-s-methyltransferase (tpmt) deficiency. azathioprine is known to induce glutathione depletion and consumption of glutathione is greate