## Abstract Surrogate endβpoint biomarkers are being developed as indicators of the efficacy of chemopreventive agents. These biomarkers are molecular and biological endβpoints that can be modulated by chemopreventive agents in accordance with their efficacy to prevent cancer. DNA hypomethylation i
β¦ LIBER β¦
Tu1172 Reversal of Colonic Hypomethylation as a Common Mechanism of Action of Chemopreventive Agents for Colorectal Cancer
β Scribed by Qi, Wentao; Hou, Lifang; Jiang, Hongmei; Kunte, Dhananjay; DeLaCruz, Mart; Gibson, Tina P.; Patel, Amir C.; Stypula, Yolanda E.; Wali, Ramesh K.; Roy, Hemant K.
- Book ID
- 122331116
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 87 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Modulation of DNA hypomethylation as a s
β
Lianhui Tao; Wei Wang; Paula M. Kramer; Ronald A. Lubet; Vernon E. Steele; Micha
π
Article
π
2004
π
John Wiley and Sons
π
English
β 171 KB
Induction of oxidative stress as a mecha
β
Rigas, B; Sun, Y
π
Article
π
2008
π
Nature Publishing Group
π
English
β 116 KB
[Recent Results in Cancer Research] Pros
β
Chan, Andrew T.; Detering, Elmar
π
Article
π
2012
π
Springer Berlin Heidelberg
β 887 KB
Development of difluoromethylornithine a
Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer
β
Frank L. Meyskens Jr.; Eugene W. Gerner
π
Article
π
1995
π
John Wiley and Sons
π
English
β 406 KB
Experimental studies have demonstrated that carcinogenesis is a multistep process in which inappropriate proliferation of cells is a critical determinant. Polyamines support sustained growth and are highly regulated in all cells. The rate limiting enzyme for this pathway is ornithine decarboxylase (
Placebo-controlled randomized trial of D
π
Article
π
1995
π
Elsevier Science
π
English
β 151 KB