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Tryptophan 2,3-dioxygenase activity in rat skin

โœ Scribed by Junko Naito; Isao Ishiguro; Yoichi Nagamura; Hisamitsu Ogawa


Book ID
115707997
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
517 KB
Volume
270
Category
Article
ISSN
0003-9861

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## Abstract The first and rateโ€limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__โ€formylkynurenine is catalyzed by two hemeโ€containing proteins, Indoleamine 2,3โ€dioxygenase (IDO), and Tryptophan 2,3โ€dioxygenase (TDO). In mammals, TDO is found exclusively in liv