Trypanosoma cruzi stocks isolated from acute Chagas disease patients lead to lethal murine infection
✍ Scribed by E.C. Oliveira; M.M.A. Stefani; D.E. Campos; A.L.S.S. Andrade; S.A. Silva; A. Rassi; A.O. Luquetti
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 412 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0035-9203
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✦ Synopsis
Ten Tiypanosoma cruzi stocks recently isolated from patients in acute and chronic phases of Chagas disease were inoculated to susceptible (A/Sri) mice.The mice were inoculated with l@ trypomastigotes intraperitoneally and monitored for parasitaemia and mortality for up to 300 d. The results demonstrated that (i) T cruzi stocks isolated from patients in the acute phase killed animals, while stocks from patients in the chronic phase did not; (ii) survival curves differed statistically among mice infected with lethal stocks, and (iii) parasite burden did not affect the mortality rate of mice.