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Trypanosoma cruzi adenine nucleoside phosphorylase: Purification and substrate specificity

✍ Scribed by Richard L. Miller; Carol L.K. Sabourin; Thomas A. Krenitsky


Book ID
115779727
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
924 KB
Volume
36
Category
Article
ISSN
0006-2952

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To compare the activity of pyrimidine nucleoside phosphorylase (PNP), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), we used uridine (Urd), deoxyuridine (dUrd), and thymidine (dThd) as substrates and human, rat, and mouse neoplastic and normal tissues. As PNP activity was higher in t