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Trypanocidal Activity of Conformationally Restricted Pentamidine Congeners

✍ Scribed by Donkor, Isaac O.; Huang, Tien L.; Tao, Bin; Rattendi, Donna; Lane, Schennella; Vargas, Marc; Goldberg, Burt; Bacchi, Cyrus


Book ID
120249329
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
238 KB
Volume
46
Category
Article
ISSN
0022-2623

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## Abstract magnified image Aiming at the development of new adamantano building blocks for treating African trypanosomiasis, we report on the synthesis of spiro adamantane 2‐imidazolines **8a‐f** and **9a‐c**, and their congeneric 5‐(1‐adamantyl)imidazolines **14** and **15**. The potency of thes