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Truncation of a Two Sample Sequential Wilcoxon Test

โœ Scribed by Eva Skovlund


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
401 KB
Volume
33
Category
Article
ISSN
0323-3847

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โœฆ Synopsis


To reduce the number of patients needed in a clinical trial, a sequential plan is sometimes used. This paper deals with the truncation of a sequential two sample Wilcoxon test which was originally an open plan (SKOVLUND and ~V A u 0 E , 1988). The truncated boundaries have been developed by stochastic simulation. These boundaries form a triangular continuation region. The simulated constante of the boundaries are presented in a table which may be used directly. Boundaries for truncation at 50, 100, 150 and 200 patients are developed. The chosen significance level may be 0.01, 0.025 or 0.05, and the power 0.95. To extend the applicability t o other treatment differences than those tabulated, smooth curves are fitted t o the simulated points. These make the test applicable t o any treatment difference within the simulated range.


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