Protein tyrosine phosphatases (PTPases) represent a family of enzymes which together with protein tyrosine kinases (PTKases) play a critical role in cell proliferation and are likely involved in neoplastic transformation. Results presented here indicate that PTPases may also be involved in mechanism
โฆ LIBER โฆ
Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts
โ Scribed by Fedele, Monica; Berlingieri, Maria Teresa; Scala, Stefania; Chiariotti, Lorenzo; Viglietto, Giuseppe; Rippel, Volkhard; Bullerdiek, Jorn; Santoro, Massimo; Fusco, Alfredo
- Book ID
- 110061441
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 379 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Protein kinase C epsilon is an oncogenic, actin nucleating protein that coordinately regulates changes in cell growth and shape. Cells constitutively expressing PKCฯต spontaneously acquire a polarized morphology and extend long cellular membrane protrusions. Here we report that the regul
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