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True and False Positive Peaks in Genomewide Scans: Applications of Length-Biased Sampling to Linkage Mapping

✍ Scribed by Joseph D. Terwilliger; William D. Shannon; G. Mark Lathrop; John P. Nolan; Lynn R. Goldin; Gary A. Chase; Daniel E. Weeks

Book ID: 117855070
Publisher: American Society of Human Genetics
Year: 1997
Tongue: English
Weight: 132 KB
Volume: 61
Category: Article
ISSN: 0002-9297
DOI: 10.1086/514855

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## Abstract When performing a genome scan in linkage or linkage disequilibrium studies to detect loci underlying complex or quantitative traits, it is important to attempt to distinguish between true and false positives using the appropriate statistical methods. There has been some controversy in t