TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization

Calcium-dependent and independent mechan

Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells

✍ Christopher A. Reilly; Mark E. Johansen; Diane L. Lanza; Jeewoo Lee; Ju-Ok Lim; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB

## Abstract Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro‐inflammatory cytokine production and cell death. The purpose of this study was to investigate the role of TRPV1‐mediated calcium flux from extracellular s