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Tropomyosin Phosphorylation Has Filament-Level And Crossbridge-Level Effects On Actin-Myosin Interactions

✍ Scribed by Rao, Vijay S.; Clobes, Amy M.; Guilford, William H.


Book ID
122950582
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
37 KB
Volume
96
Category
Article
ISSN
0006-3495

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Biochemical studies have shown that wortmannin is an inhibitor of myosin light chain (MLC) kinase (Nakanishi et al. (1992) J. Biol. Chem. 267: 2157-2163). To investigate the role of MLC kinase in smooth muscle contractions, we examined the effects of wortmannin on isolated smooth muscles of the rat