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Tritium labelling of PACAP-38 using a synthetic diiodinated precursor peptide

✍ Scribed by Martin Holst Friborg Pedersen; Michael Baun

Publisher: John Wiley and Sons
Year: 2011
Tongue: French
Weight: 178 KB
Volume: 55
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1941

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✦ Synopsis

In the interest of developing efficient methods for tritium labelling peptides, we here demonstrate the successful labelling of PACAP‐38 (pituitary adenylate cyclase‐activating polypeptide), a 38‐mer peptide, using a synthetic diiodinated PACAP‐38 precursor. In this example, we employ standard hydrogenation chemistry with the use of a heterogeneous palladium catalyst and carrier‐free tritium gas on a tritium manifold system. Copyright © 2011 John Wiley & Sons, Ltd.

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