✦ LIBER ✦
Tritium labelling of 2-(O-chlorophenyl)-2-(methylamino)-Cyclohexanone (ketamine; CI-581) by acid catalyzed exchange: An example of intramolecular competition for tritium between substituted aromatic and cyclohexanone rings
✍ Scribed by C. E. Blackburn; R. E. Ober
- Book ID
- 102373014
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- French
- Weight
- 465 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
The preparation and characterization of tritium-labelled 2-(ochlorophenyl)-2-(methylamino) cyclohexanone hydrochloride is described. Under the exchange conditions employed (CF3COOH, 10 c3H20, P t ) , it was expected that the tritium wouldbe distributed between the phenyl and cyclohexanone rings. Our observations indicated that the major portion of the tritium was located in the cyclohexanone ring.