Tritium distribution, enantiomer formation, and glycine production in L-valine labeled by microwave discharge activation of tritium gas
✍ Scribed by Richard Lee E. Ehrenkaufer; Alfred P. Wolf; Wylie C. Hembree; Seymour Lieberman
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 286 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The labeling of L‐valine by microwave discharge activation of tritium gas was found to be general (i.e., all positions were labeled) but non‐random in distribution. The α, β, and γ positions contained 7.1%, 32.7% and 60.2% respectively. On a per‐hydrogen basis the β‐position was favored by more than a factor of 3, whereas the chiral α‐position was the least labeled. Net retention of the L‐configuration was observed at the chiral center with only 1.56% D‐valine being formed. Small amounts of glycine were found to be produced by fragmentation of the alkyl side chain of valine.