Triterpenoid Saponins from the Spikes of Prunella vulgaris

✍ Scribed by Xiao-Jie Gu; You-Bin Li; Ping Li; Shi-Hui Qian; Jian-Feng Zhang

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: German
• Weight: 94 KB
• Volume: 90
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200790023

✦ Synopsis

Abstract

Three new oleanane‐skeleton triterpenoid saponins, 3__β__,4__β__,16__α__‐17‐carboxy‐16,24‐dihydroxy‐28‐norolean‐12‐en‐3‐yl 4‐O‐β‐D‐xylopyranosyl‐β‐D‐glucopyranosiduronic acid (1), (3__β__,4__β__,16__α__)‐17‐carboxy‐16,24‐dihydroxy‐28‐norolean‐12‐en‐3‐yl β‐D‐glucopyranosiduronic acid methyl ester (2), and (3__β__,4__β__)‐24‐hydroxy‐16‐oxo‐28‐norolean‐12‐en‐3‐yl 4‐O‐β‐D‐xylopyranosyl‐β‐D‐glucopyranosiduronic acid (3), together with eight known constituents, i.e., the oleanane‐type triterpenoids 4–6, and the ursane‐type triterpenoids 7–11, were isolated from the spikes of Prunella vulgaris. The new structures were established by means of detailed spectroscopic analysis (IR, HR‐ESI‐MS, 1D‐ and 2D‐NMR experiments). Compounds 1–3 were tested for their inhibition activity against the growth of tumor cell lines; only compound 3 displayed marginal inhibition activity.