Trisomy and tetrasomy for long arm of chromosome 1 in near-diploid human endometrial adenocarcinomas
✍ Scribed by J. Couturier; P. H. Vielh; R. Salmon; B. Dutrillaux
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 491 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Karyotypic analysis by R-banding after short-term culture, carried out on 7 cases of human endometrial adenocarcinoma, showed in 4 of these a trisomy or a tetrasomy for the long arm of chromosome I. In the 4 cases, these imbalances were due to rearrangements involving centromeric or para-centromeric breakpoints: 46,XX. -16, + der( I q 16p) t( I ; l6)( I p16q; I q16p); 46,XX. -21, + der (I qZI q) t( 1;21) (I p2I p; I q2I 4); 46, XX, -2I,+der(2l) t(l;2l)(qll;pl3); 48, XX, +2, +i(lq). Two other cases showed only a numerical aberration: 47, XX, + 10 and 47, XX, + 12. In the last case, only cells with apparently normal karyotype were seen. In the 4 cases with an anomaly of chromosome I, two normal I chromosomes coexisted with abnormal elements. This shows that the rearrangement very likely occurred in G2 phase of the cell cycle.