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Trisomy 21 in transient myeloproliferative disorder

✍ Scribed by M.J.W. Faed; J. Robertson; A.S. Todd; M. Sivakumaran; W.O. Tarnow-Mordi


Book ID
119104651
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
334 KB
Volume
48
Category
Article
ISSN
0165-4608

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We report the prenatal diagnosis of a transient myeloproliferative disorder suggestive of leukaemia in a fetus with hepatosplenomegaly, hydrops and 47, XY,+21 karyotype. The initial fetal white blood cell count at 26+5 weeks' gestation was 190/nl with 70 per cent blast cells. Immunophenotyping of th

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Cytologic, immunologic, and cytogenetic studies were performed on the blast cells of a newborn with Down syndrome and transient myeloproliferative disease. This hematologic disorder is uncommon, and occurs primarily in infants with Down syndrome. This boy presented with a high white blood cell count

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## Abstract Transient myeloproliferative disorder (TMD) is an uncommon syndrome strongly associated with abnormalities of chromosome 21. Blast transient proliferation appears most frequently at neonatal age and usually resolves spontaneously in two or three months. Two patients, a girl and a boy,