Trisomy 12 and p53 deletion in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: Association with morphology and resistance to conventional chemotherapy
✍ Scribed by Isabel Cano; J. Martinez; E. Quevedo; J. Pinilla; A. Martin-Recio; A. Rodriguez; A. Castañeda; R. López; T. Pérez-Piño; F. Hernández-Navarro
- Book ID
- 114136008
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 572 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0165-4608
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## Abstract The clinical, biological, and immunophenotypical characteristics of B‐cell chronic lymphocytic leukemia (B‐CLL) patients with trisomy 12 detected by fluorescence in situ hybridization (FISH) using a chromosome 12 alpha‐centromeric probe (D12Z3) were analyzed in the present study. From a
## Abstract Fluorescence in situ hybridization for the __BCR__/__ABL__ rearrangement in 138 bone marrow specimens from 59 Philadelphia^+^ (Ph^+^) chronic myelogenous leukemia (CML) patients, 35 Ph^+^ acute lymphoblastic leukemia (ALL) patients, and 57 Ph^−^ ALL patients was used. Sixteen (27.1%) of