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Trisomy 11 with MLL-PTD in a case of infant AML M0

✍ Scribed by Salvatore Serravalle; Stefania Purgato; Fraia Melchionda; Annalisa Astolfi; Roberto Tonelli; Andrea Pession


Book ID
108675350
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
775 KB
Volume
138
Category
Article
ISSN
0007-1048

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## Abstract More than 30 fusions involving the __MLL__ gene at 11q23 have been reported in acute myeloid leukemia (AML). Some of these chimeras are rather common, such as __MLL/MLLT3__(__AF9__), but many are quite rare, with some, for example, __MLL/GRAF__, described only in a single case. The __ML

An ins(X;11)(q24;q23) fuses the MLL and
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## Abstract The __MLL__ (__HRX, ALL‐1 HTRX__) gene at chromosome band 11q23 frequently is rearranged in acute lymphoblastic and myeloblastic leukemia. To date, more than 40 different 11q23 abnormalities have been described on the cytogenetic level, and at least 25 of the respective fusion partner g

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## Abstract t(X;11)(q24;q23) is a recurring chromosomal translocation in pediatric acute myeloid leukemia. The rearrangement results in fusion of __MLL__ at 11q23 with __SEPT6__ at Xq24. Here, we report the identification of an __MLL‐SEPT6__ fusion transcript in an infant with acute myeloid leukemi