Tris(2,4,6-tribromophenoxy) dichlorophosphorane: A novel condensing agent for rapid internucleotidic bond formation in the phosphotriester approach

✍ Scribed by Hitoshi Hotoda; Takeshi Wada; Mitsuo Sekine; Tsujiaki Hata

• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 235 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)95393-0

✦ Synopsis

A new class of condensing agent, tris(2,4,6-tribromophenoxy)dichlorophosphorane (BDCP), was applied to the oligodeoxyribonucleotide synthesis.

This reagent enabled us to perform a rapid internucleotidic bond formation in the phosphotriester approach only in 1 minute via an active phosphorylnitrotriazole intermediate.