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Triptolide and sorafenib combination therapy in hepatocellular carcinoma results in superior cell death in vitro and prolonged survival in vivo

✍ Scribed by Tara C.K. Krosch; Veena Sangwan; Sulagna Banerjee; Ashok K. Saluja; Selwyn M. Vickers; Eric H. Jensen

Book ID: 118469266
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 62 KB
Volume: 215
Category: Article
ISSN: 1072-7515
DOI: 10.1016/j.jamcollsurg.2012.06.350

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## Abstract Thalidomide is an immunomodulatory, antiangiogenic drug. Although there is evidence that it might be more effective in combination with chemotherapy the exact mechanism of action is unclear. Therefore, we investigated its effect in combination with metronomically applied cisplatin in a