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Triplex-Directed Interstrand DNA Cross-Linking by Diaziridinylquinone−Oligonucleotide Conjugates

✍ Scribed by Reed, Michael W.; Wald, Ansel; Meyer, Rich B.


Book ID
127176576
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
128 KB
Volume
120
Category
Article
ISSN
0002-7863

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Direct evidence for DNA intrastrand cros
✍ Stacia M Rink; Paul B Hopkins 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 312 KB

Direct evidence for DNA intrastrand cross-link formation by mechlorethamine (1) is reported. Following treatment with 1, duplex and single strand DNAs possessing two or more contiguous dG residues contained intrastrand cross-links, as revealed by the release of 2 following acid hydrolysis. Mechlore