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Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction

✍ Scribed by Salvatore Oddo; Antonella Caccamo; Jason D Shepherd; M.Paul Murphy; Todd E Golde; Rakez Kayed; Raju Metherate; Mark P Mattson; Yama Akbari; Frank M LaFerla

Book ID
117608703
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
681 KB
Volume
39
Category
Article
ISSN
0896-6273

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## Abstract Astrocytes are fundamental for brain homeostasis and are at the fulcrum of neurological diseases including Alzheimer's disease (AD). Here, we monitored changes in astroglia morphology throughout the age‐dependent progression of AD. We used an immunohistochemical approach that allows us