Triple-quadrupole LC–MS–MS for quantitative determination of nitrofuran metabolites in complex food matrixes

A novel approach to perform metabolite s

A novel approach to perform metabolite screening during the quantitative LC–MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer

✍ Wilson Z. Shou; Lisa Magis; Austin C. Li; Weng Naidong; Matthew S. Bryant 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB

## Abstract __In vitro__ metabolic stability experiments using microsomes or other liver preparations are important components in the discovery and lead‐optimization stages of compound selection in the pharmaceutical industry. Currently, liquid chromatography–tandem mass spectrometric (LC–MS/MS) su