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Triple A therapy: The molecular underpinnings of the unique sensitivity of leukemic promyelocytes to anthracyclines, all-trans-retinoic acid and arsenic trioxide

โœ Scribed by Nichol, Jessica N.; Garnier, Nicolas; Miller, Wilson H.

Book ID
122857139
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
390 KB
Volume
27
Category
Article
ISSN
1521-6926

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Differentiation therapy with all-trans retinoic acid (ATRA) has been used successfully to treat acute promyelocytic leukemia (APL), but such treatment also causes differentiation syndrome (DS) by inducing APL cell infiltration into alveolar spaces. The mechanism underlying the clearance of infiltrat