Triphosphoinositide breakdown and dense body release as the earliest events in thrombin-induced activation of human platelets

Conditions influencing release of granul

Conditions influencing release of granule contents from human platelets in citrated plasma induced by ADP or the thrombin receptor activating peptide SFLLRN: Direct measurement of percent release of β-thromboglobulin and assessment by flow cytometry of P-selectin expression

✍ Rand, Margaret L.; Perry, Dennis W.; Packham, Marian A.; Gemmell, Cynthia H.; Ye 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 695 KB

Contrary to a recent report [Rinder et al.: Blood 82:505, 19931, aspirin does inhibit the release of a-granule contents as well as inhibiting the release of dense granule contents by human platelets during ADP-induced aggregation in citrated platelet-rich plasma (PRP). Measurements were: percent rel