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Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines

✍ Scribed by Lenstra, Danny C.; Rutjes, Floris P. J. T.; Mecinović, Jasmin

Book ID
125449216
Publisher
Royal Society of Chemistry
Year
2014
Tongue
English
Weight
643 KB
Volume
50
Category
Article
ISSN
1359-7345

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✍ Jordi Garcia; Fèlix Urpí; Jaume Vilarrasa 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 273 KB

Equimolar amounts of carboxylic acids, aryl or alkyl azides, and Ph3P in refluxing benzene (hexane, toluene) afford amides in good yields. Insolubility of zwitterions Ph3&NH(CH2),COO', arising from w-azido acids and Ph3P, limits the utilization of the method for loctame formation. A plethora of phos