๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Tripeptidyl pyridinium methyl ketones as potent active site inhibitors of thrombin

โœ Scribed by Torsten Steinmetzer; Yasuo Konishi


Book ID
103983462
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
295 KB
Volume
6
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Synthesis, evaluation, and crystallograp
โœ Terry A. Lyle; Zhongguo Chen; Sandra D. Appleby; Roger M. Freidinger; Stephen J. ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 336 KB

Removal of the [3-ketoamide functionality from L-370,518 (K~ = 0.09 nM) provided a 5 nM K i inhibitor of thrombin: L-371,912. Comparison of the enzyme-inhibitor crystal structures suggests a possible explanation for the relatively small change in affinity for thrombin. L-371,912 is selective for thr

ChemInform Abstract: Synthesis, Evaluati
โœ T. A. LYLE; Z. CHEN; S. D. APPLEBY; R. M. FREIDINGER; S. J. GARDELL; S. D. LEWIS ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 36 KB ๐Ÿ‘ 2 views

Synthesis, Evaluation, and Crystallographic Analysis of L-371,912: A Potent and Selective Active-Site Thrombin Inhibitor. -Two major synthetic challenges are apparent in more efficient approaches to the synthesis of the novel trans 4-aminocyclohexylglycine ketoamide found in inhibitor (IX). The firs