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Tripeptides as selective inhibitors of src-SH2 phosphoprotein interactions

✍ Scribed by Marc Rodriguez; Renae Crosby; Krystal Alligood; Tona Gilmer; Judd Berman

Book ID: 104630501
Publisher: Springer Netherlands
Year: 1995
Tongue: English
Weight: 313 KB
Volume: 2
Category: Article
ISSN: 1573-3149
DOI: 10.1007/bf00122917

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✦ Synopsis

This paper describes the synthesis of phosphorylated peptides of the general structure Ac-Tyr(PO3HR)-Glu-Xaa-NH 2, where Xaa represents a hydrophobic 7-amino acid of D-configuration. These peptides displayed activities in the micromolar range in inhibiting src-SH2 domain/epidermal growth factor receptor interactions.

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