## Abstract The possible presence of anticipation in bipolar affective disorder and schizophrenia has led to the hypothesis that repeat expansion mutations could contribute to the genetic etiology of these diseases. Using the repeat expansion detection (RED) assay, we have systematically examined g
Trinucleotide repeat expansions: do they contribute to bipolar disorder?
โ Scribed by Dirk Goossens; Jurgen Del-Favero; Christine Van Broeckhoven
- Book ID
- 117501754
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 131 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0361-9230
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The hypothesis that expanded trinucleotide repeats contribute to the pathogenesis of schizophrenia and bipolar disorder has been recently supported by three independent studies which have shown that patients with either disorder tend to have larger CAG/CTG repeat expansion detection products than co
The hypothesis that one or more genes containing expanded trinucleotide repeats contribute to the pathogenesis of bipolar disorder has received support from three independent studies demonstrating that bipolar patients tend to have larger CAG/CTG repeat expansion detection products than controls. In