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Trimucytin, a collagen-like snake venom protein, activates platelets independent of I-domain within α2 subunit of α2β1 integrin

✍ Scribed by Chao-Zong Liu; Ting-Feng Wu; Tur-Fu Huang; Dung-Ho Wu; Guan-Ling Lin


Book ID
117257191
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
161 KB
Volume
105
Category
Article
ISSN
0049-3848

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Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified