Trimidox-Mediated Morphological Changes during Erythroid Differentiation Is Associated with the Stimulation of Hemoglobin and F-Cell Production in Human K562 Cells

Enhancement of hemoglobin and F-cell pro

Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin

✍ Iyamu, W.E.; Adunyah, S.E.; Fasold, H.; Horiuchi, K.; Elford, H.L.; Asakura, T.; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 650 KB

Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F-cells. Fetal hemoglobin (Hb F) inhibits the polymerization events of sickle hemoglobin (Hb S), thereby ameliorating the clinical symptoms of sickle cell disease. Ribonucleotide reductase