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Trimethylsilylcyanation of aldehydes and ketones catalyzed by diorganotin dichlorides

✍ Scribed by James K. Whitesell; Richard Apodaca


Book ID
103411317
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
215 KB
Volume
37
Category
Article
ISSN
0040-4039

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Trimethylsilylcyanation of aromatic alde
✍ Irina Iovel; Yuris Popelis; Mendel Fleisher; Edmunds Lukevics πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 463 KB

A series of aromatic and heterocyclic cyanohydrins and their O-silyl ethers have been synthesized by trimethylsilylcyanation of aldehydes using a catalyst generated in situ from (S,S)-2,6-bis(4'-isopropyloxazolin-2'-yl)pyridine (Pybox) with AICI 3. Mandelonitrile was prepared in isolated yield 92% w