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Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies

✍ Scribed by Jakyung Yoo; José L. Medina-Franco


Book ID
113053294
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
435 KB
Volume
18
Category
Article
ISSN
1610-2940

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✍ Narender Singh; Alfonso Dueñas-González; Frank Lyko; Jose L. Medina-Franco 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 660 KB

## Abstract **A series of DNA** methyltransferase 1 (DNMT1) inhibitors were modeled by docking and molecular dynamics studies to rationalize their activity. Our findings will be valuable in guiding research efforts toward the rational design and virtual screening of novel DNMT inhibitors.magnified