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Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa

โœ Scribed by Tamaru, Hisashi; Zhang, Xing; McMillen, Debra; Singh, Prim B.; Nakayama, Jun-ichi; Grewal, Shiv I.; Allis, C. David; Cheng, Xiaodong; Selker, Eric U.

Book ID
109918488
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
572 KB
Volume
34
Category
Article
ISSN
1061-4036

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## Abstract Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark that mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis in both breast and prostate cancers. However, the status of H3K27 methylation and its clinical