Trimethylaluminum-Promoted 1,4-Addition Reaction of Cuprates to Six or Eight-Membered 2-Hydroxymethyl Enones.

1,4-Additions of the highly functionaliz

1,4-Additions of the highly functionalized copper reagents RCu(CN)ZnI · 2 BFP3 to trisubstituted enones. A new BF3 promoted cyclization reaction

✍ Ming Chang P. Yeh; Paul Knochel; William M. Butler; Scott C. Berk 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 208 KB

The new copper reagents RCu(CN)Zn I .2 BF3 1 containing various functional groups like esters, cyanides, chlorides or enoates react with p, P'-disubstituted enones to afford the Michael adducts 4-7 in high yields (81-98%). Cyano-substituted 1,4-adducts undergo a new cyclization reaction leading to t