𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Trimetaphosphate-Induced Addition of Aspartic Acid to Oligo(glutamic acid)s

✍ Scribed by Aubrey Hill; Leslie E. Orgel

Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
106 KB
Volume
85
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

When a solution containing 0.01M decaglutamic acid, 0.1–1.0M aspartic acid, 1.0M MgCl~2~, and 0.5M sodium trimetaphosphate is allowed to stand at temperatures in the range 0–50°, addition products containing up to ten aspartic acid residues are formed. Addition occurs to the side‐chain carboxy moieties, not to the terminal amine of the decaglutamic acid. A number of other amino acids including glutamic acid, glycine, and histidine fail to react with decaglutamic acid under the same conditions. We believe that the activation of aspartic acid leads to the formation of a cyclic anhydride that is the key intermediate in the reaction.

📜 SIMILAR VOLUMES

Collision-Induced dissociations of depro
Collision-Induced dissociations of deprotonated peptides. Dipeptides containing aspartic or glutamic acids
✍ Russell J. Waugh; John H. Bowie; Roger N. Hayes 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 473 KB

## Abstract Deprotonated dipeptides, on collisional activation, fragment by the characteristic process NH~2~CH(R^1^) CONHCH(R^2^)CO~2~^−^ → NH~2~^−^C(R^1^)CONHCH(R^2^)CO~2~H → ^−^NHCH(R^2^)CO~2~H + NH~2~C(R^1^)CO, when R^1^ and R^2^ = H or alkyl. However, when one of the constituent amino acids i

Modification of aspartic acid residues t
Modification of aspartic acid residues to induce trypsin cleavage
✍ Tusn-Tien Wang; N.Martin Young 📂 Article 📅 1978 🏛 Elsevier Science 🌐 English ⚖ 240 KB

1,2-Diaminoethane and diaminomethane were coupled to aspartic acid residues in small peptides by means of a water-soluble carbodiimide. The resulting modified side chains sufficiently resembled lysine for trypsin to cleave the peptides. Similar modification of glutamic acid residues in peptides gave

Enzymatic Hydrolysis of α- and β-Oligo(L
Enzymatic Hydrolysis of α- and β-Oligo(L-aspartic acid)s by Poly(aspartic acid) Hydrolases-1 and 2 from Sphingomonas sp. KT-1
✍ Tomohiro Hiraishi; Mariko Kajiyama; Ichiro Yamato; Yoshiharu Doi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB

## Abstract **Summary:** The enzymatic hydrolysis of __α__‐ and __β__‐oligo(L‐aspartic acid)s by PAA hydrolase‐1 and PAA hydrolase‐2 (purified from __Sphingomonas__ sp. KT‐1) was performed to elucidate the mechanism of the microbial degradation by __Sphingomonas__ sp. KT‐1 of the thermally synthesi

Oxidation of L-aspartic acid and L-gluta
Oxidation of L-aspartic acid and L-glutamic acid by manganese(III) ions in aqueous sulphuric acid, acetic acid, and pyrophosphate media: A kinetic study
✍ B. S. Sherigara; K. Ishwar Bhat; Ivan Pinto; N. M. Made Gowda 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 894 KB

Kinetics of oxidation of L-aspartic acid and L-glutamic acid by manganese(II1) ions have been studied in aqueous sulphuric acid, acetic acid, and pyrophosphate media. Manganese(II1) solutions were prepared by known electrolytidchemical methods in the three media. The nature of the oxidizing species

Thermal and charge-induced coil to α-hel
Thermal and charge-induced coil to α-helix transition of poly-L-glutamic acid and random L-glutamic acid–L-alanine copolymers
✍ Akira Warashina; Akira Ikegami 📂 Article 📅 1972 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 850 KB

Thermal and charge induced random coil to a-helii transitions of poly-cglutamic acid (PGA) were measured by optical rotatory dispersion in various solvents. The data of PGA in 0.1M NaCl were analyzed by the Zimm-Rice theory. Enthalpy and entropy changes for the coil-to-helix transition in the unioni