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Trimerization of Phenylacetonitrile. InMe 3 as a Base for C−H Acidic Nitriles

✍ Scribed by Iravani, Effat; Neumüller, Bernhard


Book ID
127340254
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
133 KB
Volume
22
Category
Article
ISSN
0276-7333

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Starting from hex-5-yn-1-01 an efficient seven step synthesis of (Z)9-[2H,](non-3-en-1-yl) triphenylphosphonium bromide is described. This Wittig reagent is a key intermediate for the synthesis of C-20 trideuterated eicosanoids. Introduction of deuterium at C-20 provides standards that are stable to