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Trifunctional bispecific antibodies induce tumor cell killing of HNSCC

โœ Scribed by Silke Gronau; Michael Schmitt; Bernard Thess; Herbert Riechelmann

Book ID
117399566
Publisher
SAGE Publications
Year
2003
Tongue
English
Weight
41 KB
Volume
129
Category
Article
ISSN
0194-5998

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โœ Silke S. Gronau; Michael Schmitt; Bernard Thess; Peter Reinhardt; Markus Wiesnet ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 598 KB

## Abstract ## Background. The trifunctional bispecific antibody Removab (tbAB) bridges and activates CD3 positive T cells to EpCAM on carcinoma cells and simultaneously binds to an accessory immuneโ€cell inducing tumor cell lysis. tbABโ€induced tumor cytotoxicity was assessed in an autologous human