Trientine increases fecal copper excretion in Wilson's disease: A case report

✍ Scribed by Shozo Ishikawa; Shozo Nomoto; Kunihiro Yoshida; Takahiko Tokuda; Shu-ichi Ikeda

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 15 KB
• Volume: 14
• Category: Article
• ISSN: 0896-548X
• DOI: 10.1002/jtra.1051

✦ Synopsis

Abstract

A copper balance study was performed during the successive 7 days when a patient with Wilson's disease went on a low‐copper diet and was taking 1500 mg of trientine daily. The average copper intake was 944 μg/day, urine copper excretion was 503 μg/day, fecal copper excretion was 922 μg/day; therefore, trientine reduced body copper about 500 μg per day. We provide direct evidence that trientine maintains copper balance probably by enhancing both the urinary and fecal excretion, with a larger amount decoppered in the feces. J. Trace Elem. Exp. Med. 14:405–407, 2001. © 2001 Wiley‐Liss, Inc.