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Tricycloquinazoline carcinogenesis: Interaction of carcinogen with mouse skin proteins

✍ Scribed by R. W. Baldwin; M. Moore; M. W. Partridge

Publisher
John Wiley and Sons
Year
1968
Tongue
French
Weight
600 KB
Volume
3
Category
Article
ISSN
0020-7136

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✦ Synopsis

Following topical application of tricycloquinazoline-14C (0.03 p M ) to mice, radioactivity was covalently bound to soluble and particulate skin proteins. The maxinium level of binding to soluble proteins (equivalent to 4 . 2 ~ p M TCQlmg) was reached after 24 hours and that to particulate proteins (2.5 x TCQImg) afrer 48 hours. These binding levels are lower than those observed with carcinogenic and nori-carcinogenic hydrocarbons studit.d under similar conditions. Treatment with doses of tricycloquinazoline greater than 0.03 p M did not produce increased levels of binding. The radioactivity associated with pvoteins was liberated following treatments ( 4 N KOH or 6 N HCI) which extensively degrade proteins. None of this radioactive material was identijSable as unchanged tricycloquinazoline. In the soluble proteins, radioactivity was bound almost exclusively to protein having the mobility of albumin whilst no significant radioactivity was associated with h proteins.

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