Triclonal gammopathy (IgAk, IgGk, and IgMk) in a patient with plasmacytoid lymphoma derived from a monoclonal origin
✍ Scribed by Takashi Murata; Hiroyuki Fujita; Hiroshi Harano; Masaya Hukawa; Heiwa Kanamori; Michio Matsuzaki; Hiroshi Mohri; Jun Kudoh; Nobuyoshi Shimizu; Takao Okubo
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 478 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
We report the case of a 64-year-old woman with plasma cytold lymphoma of the ileum and gastric wall. Serum protein electrophoresis and lmmunoelectrophoresis showed a triclonal IgGK, IgAK, and lgMK gammopathy. Biopsy of the tumor revealed three different cell types, which were stained with antibodies specific for IgG, IgA, and IgM. However, DNA analysls of Immunoglobulln gene rearrangements using J, , C,, and CK gene probes showed a monoclonal pattern. These results suggest that the three types of malignant cells producing dlfferent classes of immunoglobulins were derived from a single clone of B-cells that had undergone a "class switch".