## BACKGROUND. Vasoactive intestinal peptide (VIP) is one of several small neuropeptides that affect cancer growth. A lipophilic VIP analog, stearyl-Nle 17 -neurotensin 6-11 VIP 7-28 (SNH) that inhibited lung carcinoma growth has been described previously. The experiments performed were clonogenic
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation
β Scribed by Paolo Piacentini; Massimo Donadelli; Chiara Costanzo; Patrick S. Moore; Marta Palmieri; Aldo Scarpa
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 474 KB
- Volume
- 448
- Category
- Article
- ISSN
- 1432-2307
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In memoriam to the late Philippe Vigier , Emeritus Head of the Department of Retrovirology, Institut Curie. In wartime he fought for the freedom of his country, in peacetime for the elucidation of cancer.
## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositolβ3βkinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVPβBEZ235, a novel dual PI