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Trichostatin A, a Histone Deacetylase Inhibitor, Suppresses Collagen Synthesis and Prevents TGF-β1-Induced Fibrogenesis in Skin Fibroblasts

✍ Scribed by Krista Rombouts; Toshiro Niki; Patricia Greenwel; Alain Vandermonde; Annemie Wielant; Karine Hellemans; Pieter De Bleser; Minoru Yoshida; Detlef Schuppan; Marcos Rojkind; Albert Geerts


Book ID
115604332
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
523 KB
Volume
278
Category
Article
ISSN
0014-4827

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator