Trichloroisocyanuric acid-catalyzed reaction of indoles: An expeditious synthesis of bis-indolyl, tris-indolyl, di(bis-indolyl), tri(bis-indolyl), and tetra(bis-indolyl)methane under solid-state conditions

✍ Scribed by Hojat Veisi; Reza Gholbedaghi; Javad Malakootikhah; Alireza Sedrpoushan; Behrooz Maleki; Davood Kordestani

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 146 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.486

✦ Synopsis

Abstract

magnified image Trichloroisocyanuric acid is found to be an efficient catalyst for the electrophilic substitution reaction of indole with aldehydes/ketones to afford the corresponding bis‐indolyl, tris‐indolyl, di(bis‐indolyl), tri(bis‐indolyl), and tetra(bis‐indolyl)methanes under solid‐state conditions by pulverization‐activation method at room temperature with excellent yields. The remarkable features of this new procedure are high conversions, shorter reaction times, cleaner reaction profiles, and simple experimental and work‐up procedures. J. Heterocyclic Chem., (2010).